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Copyright (c) 2022 James Wells, Olaf Kosch, Shailey Twamley, Antje Ludwig, Joran Paeye, Hendrik Paysen, Frank Wiekhorst
This work is licensed under a Creative Commons Attribution 4.0 International License.
Magnetic field hyperthermia (MFH) therapy is an emerging cancer treatment which uses heat to damage tumors. Like magnetic particle imaging (MPI), MFH combines injected magnetic nanoparticles with the subsequent application of time-varying magnetic fields. One potential application of MPI technology is in aiding the optimization and safety of MFH therapy. This work reports recent successes in demonstrating how Lissajous scanning magnetic particle imaging can act as a multi-functional platform to support the safe and optimized application of MFH therapy. Lissajous scanning MPI can i) image magnetic nanoparticles in-vivo to verify that they are correctly located within the tumor tissue before heat generation begins, ii) generate spatially-focused heating using the Lissajous scanning magnetic field sequences iii) produce 3D images of the elevated temperatures generated during therapy in real-time. Recent achievements in developing the capability for realizing accurately calibrated temperature-resolved 3D “multi-colour” Lissajous MPI via the system matrix technique are also reported.
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