Main Article Content
Copyright (c) 2022 Timo Herrmann
This work is licensed under a Creative Commons Attribution 4.0 International License.
The treatment of implant-associated infection is still a considerable issue in modern orthopaedical surgery. A promising candidate to improve this are superparamagnetic, drug loaded nanoparticles in combination with a magnetizable implant and an external magnetic field. This set-up enhances the accumulation of the magnetic nanoparticles at the targeted implant, thus reducing the number of nanoparticles needed for a successful treatment. Pivotal for the superparamagnetic nanoparticles are a preferably high magnetization and a sufficient long circulation time within the body. A poly(ethyleneglycol) (PEG) functionalization is widely used to increase the circulation time. Since a PEG functionalization adds mass to a nanoparticle, which influence its properties, we functionalized magnetic nanoporous silica nanoparticles (MNPSNP) with PEG moieties of different chain length and studied the effect of the chain length of the saturation magnetization on the particles.
 H. C. Janßen, N. Angrisani, S. Kalies, F. Hansmann, M. Kietzmann, D. P. Warwas, P. Behrens, J. Reifenrath, J. Nanobiotechnology 2020, 18, 14.
 A. S. Karakoti, S. Das, S. Thevuthasan, S. Seal, Angew. Chem. Int. Ed. 2011, 50, 1980.
 M. D. Howard, M. Jay, T. D. Dziubla, X. Lu, J. Biomed. Nanotechnol. 2008, 4, 133.
 V. Cauda, C. Argyo, T. Bein, J. Mater. Chem. 2010, 20, 8693.