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Magnetic Particle Imaging (MPI) is a relatively new medical imaging technology that can find information about the location of a specific disease using nanomagnetic particles with superparamagnetism. After Gleich and Weizencker published a paper on the basic theory and application of MPI in 2005, many studies have published various techniques for MPI. Our research team has made three types of MPI system so far and obtained the images for mouse-sized samples. The generation of Field Free Line (FFL) is basically based on permanent magnets, and the acquisition and processing of signals is based on FMMD. The first one is to hold the permanent magnet stationary and move the imaging object. The second system is to create FFL by mixing a permanent magnet and an electromagnet. The generated FFL is moved mechanically . The third method uses permanent magnets to create FFL and moves them mechanically. Compared to the electromagnet based MPI system, all three MPI systems above can be manufactured and operated at a very low cost in the power and cooling system. However, this study shows that even if the same FFL generation and signal acquisition principles are used, the development direction of commercialization and large-scale research can be different depending on whether the sample is fixed or moved). Since the issues discussed here can be applied to MPI based on permanent magnets in common, it is considered that this can contribute to the development of MPI.
 S.-M. Choi, J.-C. Jeong, J. Kim, E.-G. Lim, C.-b. Kim, S.-J. Park, D.-Y. Song, H.-J. Krause, H. Hong, I.S. Kweon, A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics, Scientific Reports 10(1) (2020) 11833.