International Journal on Magnetic Particle Imaging IJMPI
Vol. 10 No. 1 Suppl 1 (2024): Int J Mag Part Imag

Proceedings Articles

A receive insert for non-human primate functional MPI (fMPI)

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Jorge Chacon-Caldera (The MGH/HMS Martinos Center for Biomedical Imaging), Eli Mattingly , Monika Sliwiak , Alex C. Barksdale , Frauke H. Niebel , Lawrence L. Wald 


We designed and built a receive gradiometer coil for non-human primate (NHP) fMPI studies. The coil was integrated and tested within our human-size brain MPI system. We demonstrate the imaging resolution and sensitivity expected in NHP studies using a dilusion series sensitivity measurement (120 µg to 23 ng iron mass) and a NHP-brain-sized phantom with an iron concentration of 62.5 µg/mL, below the level expected in arterial blood in MPI (143.0 µg/mL). Using 6 mT drive amplitudes and producing one 12.8 cm field-of-view image every 4.7 seconds resulted in a detection limit (SNR = 1) of 19.5 ng of iron in 2D imaging and good image quality. This would correspond to a contrast-to-noise ratio (CNR) of 20 for a 25% change of cerebral blood volume (CBV) following activation in a 6 mm isotropic voxel. These promising preliminary sensitivity levels encourage the pursuit of the first in vivo brain function MPI experiments in primates.

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