International Journal on Magnetic Particle Imaging IJMPI
Vol. 12 No. 1 Suppl 1 (2026): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2026.2605002

Proceedings Articles, ID 972

MPI-CT: Dual-Modality imaging and reconstruction system

Main Article Content

Keyi Tang (Soochow University), Wei Zhao (Medical School, Nanjing University), Jianghao Zhao (School of Software, Northwestern Polytechnical University), Longqi Zhan (School of Biological Science and Medical Engineering, and Jiangsu Key Laboratory for biomaterials and devices, Southeast University,), Ze Liu (School of Biological Science and Medical Engineering, and Jiangsu Key Laboratory for biomaterials and devices, Southeast University), Shouhua Luo (School of Biological Science and Medical Engineering, and Jiangsu Key Laboratory for biomaterials and devices, Southeast University), Chunyi Liu (Medical School, Nanjing University), Ning Gu (Medical School, Nanjing University)

Copyright (c) 2026 Keyi Tang, Wei Zhao, Jianghao Zhao, Longqi Zhan, Ze Liu, Shouhua Luo, Chunyi Liu, Ning Gu

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Magnetic particle imaging (MPI) is an emerging functional molecular imaging technique capable of real-time, quantitative visualization of superparamagnetic iron oxide nanoparticles (SPIONs). However, the lack of anatomical information limits its standalone diagnostic capability. To address this, we developed an MPI-CT dual-modality imaging system that integrates molecular sensitivity with structural precision. The system employs a sequential acquisition strategy to achieve spatially co-registered multimodal imaging. The MPI subsystem operates under a 3 T/m gradient field and achieves a spatial resolution of 1.0 mm. The spectral computed tomography (CT) subsystem consists of an X-ray emission unit, a photon-counting detector, a motion control unit, and a centralized data processing module. Finally, a mouse–magnetic particle phantom was fabricated for experimental validation, and dual-modality fusion of MPI and spectral CT images was successfully achieved, demonstrating the feasibility of high-resolution, quantitative MPI-CT imaging.

Article Details

References

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