HYPER localized hyperthermia – early results

Matthias Weber; Daniel Hensley; Blayne Kettlewell; Andrew Mark; Ryan Orendorff; Maximilian Peters; Brice Tiret; Elaine Yu; Patrick Goodwill

doi:10.18416/IJMPI.2020.2009061

International Journal on Magnetic Particle Imaging IJMPI
Vol. 6 No. 2 Suppl 1 (2020): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2020.2009061

Proceedings Articles

HYPER localized hyperthermia – early results

Matthias Weber (Magnetic Insight), Daniel Hensley , Blayne Kettlewell , Andrew Mark , Ryan Orendorff , Maximilian Peters , Brice Tiret , Elaine Yu , Patrick Goodwill

Abstract

In magnetic fluid hyperthermia (MFH), Magnetic Nanoparticles (MNPs) dissipate heat when exposed to alternating magnetic fields (AMF). MFH is used for targeted energy deposition for targeted drug-delivery or cancer therapy. To avoid heat deposition in all areas with high particle concentration, a gradient field featuring a field-free area (FFR) can be utilized to isolate heating a target region. In this work, we present preliminary results with a localized hyperthermia system, HYPER, that features a mechanically actuated gradient that enables adjusting the heating region’s size and position. The size of the heating region in our prototype is verified by measuring the full width at half maximum (FWHM) of the specific absorption rate (SAR) point spread function (PSF) and compared to a theoretical heating model.

Int. J. Mag. Part. Imag. 6(2), Suppl. 1, 2020, Article ID: 2009061, DOI: 10.18416/IJMPI.2020.2009061

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