International Journal on Magnetic Particle Imaging IJMPI
Vol. 8 No. 1 Suppl 1 (2022): Int J Mag Part Imag

Proceedings Articles

Changing iron content and excitation field: Comparative study of Synomag® nanoparticles

Main Article Content

Lejla Alic (University of Twente), Kalthoum Riahi (University of Twente), Melissa M. Horstman – van de Loosdrecht (University of Twente), Max T. Rietberg , Javier Perez y Perez , Corné Dijkstra , Bennie ten Haken 


Magnetic nanoparticles (MNPs) are widely used to facilitate magnetic particle imaging (MPI) which has the potential to become the leading diagnostic instrument for biomedical imaging. This comparative study assesses the effects of changing iron content and excitation frequency on point-spread function (PSF) representing the effect of magnetization reversal. PSF is quantified by features of interest for MPI: i.e. gradient amplitude and full-width-at-half-maximum (FWHM). A superparamagnetic quantifier (SPaQ) is used to assess differential magnetic susceptibility of two commercially available MNPs: Synomag®-D50 and Synomag®-D70. For both MNPs, the signal output depends on increase in drive field frequency and amount of iron-oxide, which might be hampering the sensitivity of MPI systems that perform on higher frequencies. Nevertheless, there is a clear potential of Synomag®-D for a stable MPI resolution, especially in case of 70 nm version, that is independent of either drive field frequency or amount of iron-oxide.

Article Details


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