International Journal on Magnetic Particle Imaging IJMPI
Vol. 9 No. 1 Suppl 1 (2023): Int J Mag Part Imag

Proceedings Articles

High-order Debye model for nanoparticle magnetization in magnetic particle imaging

Main Article Content

yimeng li (Beihang University), Peng Zhang , Xin Feng , Hui Hui , Jie Tian 

صندلی اداری سرور مجازی ایران Decentralized Exchange


Magnetic particle imaging (MPI) is a new medical modality to safely and sensitively image the concentration distribution of superparamagnetic iron-oxide nanoparticle (SPIO). It relies on the nonlinear magnetization response of SPIO under time-varying magnetic field to induce output voltage signal. When the multidimensional magnetic fields are applied in MPI, the commonly used first-order Debye model decreases accuracy in modeling the magnetization of SPIO. To solve this problem, we propose a high-order Debye model, which considers the contribution of each dimensional magnetic field on the magnetization of SPIO. Through various experiments, the proposed high-order Debye model shows superiority over the first-order Debye model, with 30% lower root-mean-square error in modeling the magnetization. Using the high-order Debye model, the influence of different magnetic fields on the SPIO can be accurately analyzed, and this model can further provide guidance for MPI instrument optimization.

Article Details


[1] B. Gleich and J. Weizenecker. Tomographic imaging using the nonlinear response of magnetic particles. Nature, 435(7046):1214–1217, 2005.
[2] W. Tong, H. Hui, W. Shang, Y. Zhang, F. Tian, Q. Ma, X. Yang, J. Tian, and Y. Chen. Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidasetargeted nanoparticles. Theranostics, 11(2):506, 2021.
[3] C. Shasha and K. M. Krishnan. Nonequilibrium dynamics of magnetic nanoparticles with applications in biomedicine. Advanced Materials, 33(23):1904131, 2021.
[4] L. R. Croft, P. W. Goodwill, and S. M. Conolly. Relaxation in x-space magnetic particle imaging. IEEE transactions on medical imaging, 31(12):2335–2342, 2012.
[5] P. W. Goodwill and S. M. Conolly. Multidimensional x-space magnetic particle imaging. IEEE transactions on medical imaging, 30(9):1581–1590, 2011.
[6] T. Kluth, P. Szwargulski, and T. Knopp. Towards accurate modelingof the multidimensional magnetic particle imaging physics. New journal of physics, 21(10):103032, 2019.

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