International Journal on Magnetic Particle Imaging IJMPI
Vol. 9 No. 1 Suppl 1 (2023): Int J Mag Part Imag

Short Abstracts

Low-cost standalone magnetic particle spectroscopy device for fast and sensitive immunoassays

Main Article Content

Florian Wolgast (Institut für elektrische Messtechnik und Grundlagen der Elektrotechnik and LENA, TU Braunschweig, Germany), Tamara Kahmann (Institut für elektrische Messtechnik und Grundlagen der Elektrotechnik and LENA, TU Braunschweig, Germany), Meinhard Schilling (Institut für elektrische Messtechnik und Grundlagen der Elektrotechnik and LENA, TU Braunschweig, Germany), Frank Ludwig (Institut für elektrische Messtechnik und Grundlagen der Elektrotechnik and LENA, TU Braunschweig, Germany), Thilo Viereck (Institut für elektrische Messtechnik und Grundlagen der Elektrotechnik and LENA, TU Braunschweig, Germany)

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Abstract

The recent pandemic has shown how important reliable assays are for determining whether someone is infectious. One promising alternative to the established testing methods are immunoassays with magnetic nanoparticle (MNP) markers using magnetic particle spectroscopy (MPS). In this work we present the development of our “immunoMPS” which was especially built at low cost for immunoassays with infectious samples. It is a completely self-contained, mobile device with total costs of only 300€ that could be used in S2+ laboratories. The device delivers high performance on par or exceeding our lab equipment. Thus, we achieved a significantly lower limit of detection (LOD) of 4x10^8 viruses/mL of our magnetic immunoassays (MIAs) for the detection of mimic SARS-CoV-2 which is about one order of magnitude better than previous results in this research topic. In addition, it is possible to further improve the limit by optimizing the experimental setup and using DC fields.

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