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Magnetic Particle Imaging hardware has reached human scale and thus patient safety questions and clinical application scenarios are in the focus of current research. In this work, we present a safe real-time 3D MPI system
for cerebral applications. High voltages are avoided to ensure patient safety by a low voltage-high current transmit coil design. The developed 2D drive-field generator generates a field-free-point trajectory in the sagittal xz-plane
that is shifted by a dynamic selection-field sequence along the y-axis. The scanner generates 3D images with 4 frames/second and allows for direct visualization of the clinically preferred transversal yz-plane, which is crucial
for future brain examinations. Advanced reconstruction techniques reach a system sensitivity of 4 ?gFe with respect to the iron mass in a sensitivity study.