International Journal on Magnetic Particle Imaging IJMPI
Vol. 9 No. 1 Suppl 1 (2023): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2023.2303045

Proceedings Articles

Safe and Rapid 3D Imaging: Upgrade of a Human-Sized Brain MPI System

Main Article Content

Florian Thieben (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany), Fabian Mohn (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany), Fynn Foerger (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany), Niklas Hackelberg (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany), Jan-Philipp Scheel (Fraunhofer Research Institute for Individualized and Cell-based Medicine, Lübeck, Germany; Institute for Medical Engineering, University of Lübeck, Lübeck, Germany), Matthias Graeser (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany; Fraunhofer Research Institute for Individualized and Cell-based Medicine, Lübeck, Germany; Institute for Medical Engineering, University of Lübeck, Lübeck, Germany), Tobias Knopp (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany)

Abstract

Magnetic Particle Imaging hardware has reached human scale and thus patient safety questions and clinical application scenarios are in the focus of current research. In this work, we present a safe real-time 3D MPI system
for cerebral applications. High voltages are avoided to ensure patient safety by a low voltage-high current transmit coil design. The developed 2D drive-field generator generates a field-free-point trajectory in the sagittal xz-plane
that is shifted by a dynamic selection-field sequence along the y-axis. The scanner generates 3D images with 4 frames/second and allows for direct visualization of the clinically preferred transversal yz-plane, which is crucial
for future brain examinations. Advanced reconstruction techniques reach a system sensitivity of 4 ?gFe with respect to the iron mass in a sensitivity study.

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