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Stimulus-triggered drug release by magnetic actuation of nano drug carriers is of high interest for targeted therapies. Most promising candidates are nano formulations based on biodegradable polymers and magnetic nanoparticles (MNP) because they have low side effects and customizable degradation properties. For the control drug release in vivo, monitoring of degradation dynamics play an important role. In this study, we demonstrate the feasibility of measuring degradation state of poly-(lactic-co-glycolic) acid magnetic nanoparticles (PLGA-MNP) using magnetic particle imaging (MPI). We show that due that the immobilization state of MNP during degradation leads to changes in image quality. Further, we test the influence of magnetic fluid hyperthermia on degradation of PLGA-MNP carriers and discuss the effects of degradation on MPI signal.