International Journal on Magnetic Particle Imaging IJMPI
Vol. 9 No. 1 Suppl 1 (2023): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2023.2303016

Proceedings Articles

Assessing degradation of nano drug carriers - Magnetic particle imaging as a solution

Main Article Content

Oliver Reisen (Institute of Applied Medical Engineering, RWTH Aachen University), Max Schoenen (Institute of Applied Medical Engineering, RWTH Aachen University), Sven Schober (Institute of Applied Medical Engineering, RWTH Aachen University), Thomas Schmitz-Rode (Institute of Applied Medical Engineering, RWTH Aachen University), Ioana Slabu (Institute of Applied Medical Engineering, RWTH Aachen University)

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Abstract

Stimulus-triggered drug release by magnetic actuation of nano drug carriers is of high interest for targeted therapies. Most promising candidates are nano formulations based on biodegradable polymers and magnetic nanoparticles (MNP) because they have low side effects and customizable degradation properties. For the control drug release in vivo, monitoring of degradation dynamics play an important role. In this study, we demonstrate the feasibility of measuring degradation state of poly-(lactic-co-glycolic) acid magnetic nanoparticles (PLGA-MNP) using magnetic particle imaging (MPI). We show that due that the immobilization state of MNP during degradation leads to changes in image quality. Further, we test the influence of magnetic fluid hyperthermia on degradation of PLGA-MNP carriers and discuss the effects of degradation on MPI signal.

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