International Journal on Magnetic Particle Imaging IJMPI
Vol. 10 No. 1 Suppl 1 (2024): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2024.2403031
In Vitro Detection of Gastrointestinal Bleeding using Single- and Multi-Contrast MPI
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Copyright (c) 2024 Fabian Mohn, Patryk Szwargulski, Michael Gerhard Kaul, Matthias Graeser, Tobias Mummert, Kannan M. Krishnan, Tobias Knopp, Gerhard Adam, Johannes Salamon, Christoph Riedel
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Abstract
Gastrointestinal (GI) bleeding is a potentially life-threatening condition that is typically diagnosed using radiation based imaging modalities such as computed tomography (CT) or catheter-based angiography. Magnetic Particle Imaging (MPI) could provide non-invasive, real-time volumetric imaging without ionizing radiation in future human-sized scanners that covers the entire GI tract. We have developed a human-sized (3D printed) phantom that represents both the bowel lumen and the vascular compartment of the bowel wall. One version has a perforation between the two compartments and a control phantom does not. For single contrast MPI, we evaluate the fluid exchange between the two lumen by observing an administered blood pool tracer. For multi-contrast MPI, the intestinal lumen was filled with an intestinal tracer, which represents an orally administered tracer, to allow co-registration of both tracers at the same location. Both single- and multi-contrast MPI are feasible to visualize GI bleeding and MPI may prove to be a useful tool for radiation-free detection of bleeding throughout the GI tract.