International Journal on Magnetic Particle Imaging IJMPI
Vol. 10 No. 1 Suppl 1 (2024): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2024.2403031

Proceedings Articles

In Vitro Detection of Gastrointestinal Bleeding using Single- and Multi-Contrast MPI

Main Article Content

Fabian Mohn , Patryk Szwargulski (Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany), Michael Gerhard Kaul (Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany), Matthias Graeser (Fraunhofer Research Institute for Individualized and Cell-based Medicical Engineering, IMTE, Lübeck, Germany and Institute of Medical Engineering, University of Lübeck, Lübeck, Germany), Tobias Mummert (Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany), Kannan M. Krishnan (Department of Materials Science and Engineering, University of Washington, Seattle, USA), Tobias Knopp (Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, Hamburg, Germany and Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany and Fraunhofer Research Institute for Individualized and Cell-based Medicical Engineering, IMTE, Lübeck, Germany), Gerhard Adam (Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany), Johannes Salamon (Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany), Christoph Riedel (Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany)

Copyright (c) 2024 Fabian Mohn, Patryk Szwargulski, Michael Gerhard Kaul, Matthias Graeser, Tobias Mummert, Kannan M. Krishnan, Tobias Knopp, Gerhard Adam, Johannes Salamon, Christoph Riedel

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Gastrointestinal (GI) bleeding is a potentially life-threatening condition that is typically diagnosed using radiation based imaging modalities such as computed tomography (CT) or catheter-based angiography. Magnetic Particle Imaging (MPI) could provide non-invasive, real-time volumetric imaging without ionizing radiation in future human-sized scanners that covers the entire GI tract. We have developed a human-sized (3D printed) phantom that represents both the bowel lumen and the vascular compartment of the bowel wall. One version has a perforation between the two compartments and a control phantom does not. For single contrast MPI, we evaluate the fluid exchange between the two lumen by observing an administered blood pool tracer. For multi-contrast MPI, the intestinal lumen was filled with an intestinal tracer, which represents an orally administered tracer, to allow co-registration of both tracers at the same location. Both single- and multi-contrast MPI are feasible to visualize GI bleeding and MPI may prove to be a useful tool for radiation-free detection of bleeding throughout the GI tract.

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