International Journal on Magnetic Particle Imaging IJMPI
Vol. 10 No. 1 Suppl 1 (2024): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2024.2403017

Proceedings Articles

Magnetic particle imaging can be used to assess tumour associated macrophage density in vivo

Main Article Content

Nitara Fernando (Western University), Julia Gevaert , Paula Foster 

Copyright (c) 2024 Nitara Fernando, Julia Gevaert, Paula Foster

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Tumour Associated Macrophages (TAMs) play a crucial role in breast cancer prognosis. Here we propose Magnetic Particle Imaging (MPI) for non-invasive TAM assessment. By employing an advanced reconstruction algorithm and a small field of view (FOV) focused on the tumour, we demonstrate enhanced image quality and successful quantification of TAMs in mouse mammary tumours with different metastatic potentials (4T1 and E0771). Utilizing in vivo MPI, we did not see significant differences in the MPI signal for 4T1 tumours compared to E0771. These findings highlight the potential of MPI for in vivo TAM quantification despite dynamic range limitations, offering a promising avenue for broader applications in cancer research and potentially overcoming constraints in other in vivo imaging contexts. 

Article Details

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