Biocompatibility of sulfobetaine and PEG 25 kDa functionalized synomag®-D

Abstract

The method of magnetic particle imaging relies crucially on the accessibility of adequate tracer materials. Those have to
fulfill different technical requirements like high signal strength but also high biocompatibility, in particular hemocompatibility, and
high blood circulation time since magnetic nanoparticles are applied intravascular in most applications. In order to further improve these properties, high-performing synomag®-D was optimized within the present study by coupling of sulfobetaine or PEG 25 kDaOMe. Relative cell viability of these functionalized magnetic nanoparticles was found to be 8 to 18% higher compared to commercially available Resotran® while observed activation of the coagulation system was slightly faster. Thus, sulfobetaine and PEG 25 kDa-OMe functionalized synomag®-D present promising candidates for further investigations with respect to their behavior in vivo.