Preventing Interference Between Saturation Coil and Receive Coil in MPI

Abstract

In magnetic particle imaging (MPI), the signals received from magnetic nanoparticles (MNPs) are directly proportional to concentration. Hence, accumulation of MNPs in off-target organs may overpower the signal from actual regions-of-interest that contain MNPs at a smaller concentration. We previously proposed placing a saturation coil over the off-target organ to locally suppress its signal. However, the saturation coil caused a large interference signal on the receive coil, necessitating the acquisition of a separate baseline to determine the interference signal. In this work, we propose methods to prevent the interference between the saturation coil and the receive coil to enable localized signal suppression without the need for an additional baseline acquisition.