International Journal on Magnetic Particle Imaging IJMPI
Vol. 12 No. 1 Suppl 1 (2026): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2026.2604001

Proceedings Articles, ID 956

Stimulated emission depletion (STED) magnetic particle imaging

Main Article Content

Guang Jia (Xidian University), Yongchen Gou (Xidian University), Zhongwei Bian (Beihang University), Tianshu Li (Xidian University), Shi Bai (Shenyang University of Technology), Yiwen Li (Xidian University), Peng Gao (Xidian University), Tanping Li (Xidian University), Hui Hui (Chinese Academy of Sciences), Jie Tian (Chinese Academy of Sciences)

Copyright (c) 2026 Guang Jia, Yongchen Gou, Zhongwei Bian, Tianshu Li, Shi Bai, Yiwen Li, Peng Gao, Tanping Li, Hui Hui, Jie Tian

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Magnetic Particle Imaging (MPI) enables in vivo magnetic nanoparticle detection for cell tracking and molecular
imaging, but human-sized scanners only reach 5-10 mm resolution, insufficient for precise localization. This study
proposes a high-resolution MPI method via the STED principle and donut-shaped points spread function(PSF): a
DCoffset stimulation field exceeding excitation field amplitude forms a donut focal spot , theoretically validated
by Chebyshev polynomials. Experiments and simulations on field-free-region MPI scanners confirmed donut
PSFs. Optimized STEDfactor-based PSF subtraction yielded smaller FWHM, enabling sub-millimeter resolution
reconstruction. The STED-inspired donut PSF improves MPI resolution by breaking the Langevin magnetization
barrier.

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