Performance evaluation of different surface receiving coils using single-sided magnetic particle spectrometer

Abstract

Magnetic particle imaging (MPI) is an emerging molecular imaging technique characterized by high sensitivity and high resolution. The single-sided MPI system, owing to its compact size and high portability, is well-suited for clinical use. However, it faces challenges in detection depth and sensitivity, and relies heavily on receiver coils. This study investigates the impact of different surface receiver coil topologies on the performance of single-sided magnetic particle spectrometers under strict constraints of fixed wire length. Through electro-magnetic simulation and characterization of ring-shape, solenoid, raceway, single-D, double-D, and gradient annular coils, the results reveals that distinct performance trade-offs emerge across different topologies. Ring-shaped, track-shaped, and single D-shaped coils demonstrate superior surface sensitivity, while solenoid coils excel in providing a large-area magnetic response zone within the coil. Further analysis reveals that double-D coils can achieve two distinct spatial sensitivity distributions (elliptical wide-field or figure-eight gradient fields) depending on the connection mode. This dual capability of double-D coils holds potential for biomedical applications like highly sensitive tumor screening and precise localization.