International Journal on Magnetic Particle Imaging IJMPI
Vol. 12 No. 1 Suppl 1 (2026): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2026.2603041

Proceedings Articles, ID 994

Domain-weighted Block Coordinate Descent for quantitative single-sided MPI reconstruction

Main Article Content

Lingwen Hou (School of Life Science and Technology, Xidian University), kaixiong Yang (School of Life Science and Technology, Xidian University), Yihan Wang (School of Life Science and Technology, Xidian University), Shouping Zhu (School of Life Science and Technology, Xidian University)

Copyright (c) 2026 Lingwen Hou, kaixiong Yang, Yihan Wang, Shouping Zhu

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Single-sided Magnetic Particle Imaging (MPI) provides a solution suitable for intraoperative localization. However, asymmetric coil arrangements cause nonuniform magnetic fields and depth-dependent sensitivity decay, leading to biased reconstructions. This paper proposes a domain-weighted Block Coordinate Descent (DW-BCD) algorithm for quantitative single-sided MPI reconstruction. A preliminary reconstruction estimates the signal support domain, from which weighting and regional partitioning are derived. The subsequent reconstruction combines block-wise domain-weighted  and global total variation(TV) regularization. Experiments show that DW-BCD effectively reduces depth-related concentration bias, enabling accurate quantitative reconstruction of magnetic nanoparticle distributions for clinical applications of single-sided MPI.

Article Details

References

[1] T. Knopp et al., “Weighted iterative reconstruction for magnetic particle imaging,” Physics in medicine and biology, vol. 55, pp. 1577–89, Feb. 2010, doi: 10.1088/0031-9155/55/6/003.
[2] B. Gleich and J. Weizenecker, “Tomographic imaging using the nonlinear response of magnetic particles,” Nature, vol. 435, no. 7046, Art. no. 7046, June 2005, doi: 10.1038/nature03808.
[3] Q. Wang et al., “Single-sided Magnetic Particle Imaging Device with Offset Field based Spatial Encoding,” IEEE Transactions on Medical Imaging, pp. 1–1, 2024, doi: 10.1109/TMI.2024.3522979.