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Magnetic fluid hyperthermia (MFH) is a promising non-invasive therapy. Magnetic particle imaging (MPI) is a novel quantitative imaging technique determining the local concentration of magnetic nanoparticles with high sensitivity, and high temporal-spatial resolution. Successful implemention of MPI-guided localized MFH have been reported, which shows great potential for precision diagnosis and treatment of tumors. However, real-time 3D MPI-guided localized MFH hasn’t been reported, which is promising for understaning the the treatment process and molecular mechanism of MFH. Here, we present a proof-of-concept design of a 3D Cartesian scanning MPI device with a radiofrequency coil capable of localized MFH. A proof-of-concept simulation study is conducted to evaluate the feasibility of designed coils, designed 3D MPI mode and designed localized mode. The simultion results show the designed MPI device has the potential to realize the real-time 3D MPI-guided localized MFH.