Sample preparations for reproducible measurements in MPS and MPI

Abstract

MPI is a promising new technology for highly sensitive medical imaging. To acquire reproducible measurements,stable scanner and sample preparations are needed for both system matrix (SM) acquisition and measurement.Therefore, it is important to analyze and subsequently minimize the influence of the scanner hardware, as wellas of the preparation method. In this work, we studied the evolution of the MPI signal of particle samplesusing five sealing methods (tape, hot glue, silicone, silicone + tape, UV glue) in combination with two differenttracers (perimag® and SHP20). In a background examination, we obtained high variations in the signal of theempty scanner over time. For the sample preparation series, we saw that for each type of tracer a differentsealing method worked best. Our results offer insight to sample behavior, which is important for stable SMmeasurements as well as the differentiation of other factors influencing a sample measurement.