International Journal on Magnetic Particle Imaging IJMPI
Vol 9 No 1 Suppl 1 (2023): Int J Mag Part Imag
MPI-guided endovascular therapy of 3D printed human aneurysms
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Endovascular treatment of human aneurysms with stent grafts is an established therapeutic strategy to treat ruptured and unruptured arterial aneurysms. These stents are covered with a membrane that blocks blood flow to the aneurysm and promotes healing of the vessel. To date, digital subtraction angiography (DSA) has been gold standard for image-guided stent graft application. However, DSA is associated with significant disadvantages including its invasiveness, the need for potentially nephrotoxic iodine-based contrast agents and exposure to ionizing radiation for patients and clinical staff. Magnetic particle imaging (MPI) is a fast and sensitive tomographic imaging technique that uses magnetic fields to visualize superparamagnetic iron-oxide nanoparticles (SPIONs). The advantages of MPI include the background- and radiation-free visualization of SPION-tracers. The aim of this proof-of-concept study was to demonstrate the potential of MPI for image-guided application of covered stents in a 3D printed realistic aneurysm phantom.