International Journal on Magnetic Particle Imaging IJMPI
Vol. 10 No. 1 Suppl 1 (2024): Int J Mag Part Imag

Short Abstracts

Preliminary Results: Large Bore Clinical MPI System Imaging Human Head-sized FOVs

Main Article Content

Erica E Mason (Magnetic Insight, Inc.), Elliott Barcikowski (Magnetic Insight, Inc.), John Carl (Magnetic Insight, Inc.), Mike Chandeeing (Magnetic Insight, Inc.), Bryanna Davison (Magnetic Insight, Inc.), Benjamin Fellows (Magnetic Insight, Inc.), Walter Fetsch (Magnetic Insight, Inc.), Kyle Fields (Magnetic Insight, Inc.), Joan Greve (Magnetic Insight, Inc.), Justin J Konkle (Magnetic Insight, Inc.), Eli Mattingly (Magnetic Insight, Inc.), Toby Sanders (Magnetic Insight, Inc.), Olivia Sehl (Magnetic Insight, Inc.), David Trease (Magnetic Insight, Inc.), Ashley Truxal (Magnetic Insight, Inc.), Marcela Weyhmiller (Magnetic Insight, Inc.), Patrick W Goodwill (Magnetic Insight, Inc.)


Clinical-scale MPI development has, so far, typically been optimized toward specific body parts and/or clinical applications, including functional brain imaging[1], perfusion[2], interventional[3], and cardiac imaging[4]. These systems have magnet free bore sizes in the range of 20-45 cm[1]–[3], [5], [6]. To date, the largest field of view MPI images published are 10 x 14 cm2[2] and 11 x 12 cm2[3]. Also, previous assessments of magnetostimulation have focused on the transmit field[7]–[9]. 

In this work, we present progress in our development of a general-purpose, human-scale MPI system capable of imaging large fields of view used clinically in MRI and CT. We show the overall hardware design, phantom imaging results, and human magnetostimulation results for all magnetic fields (i.e., gradient, drive, and slow shift) experienced during imaging.  

The main magnet has a 60 cm magnet free bore and is designed to fit the shoulders. The magnet produces a field-free point with a measured performance of 0.6 T/m at 40 kW of power dissipation. A water-cooled head/extremity coil produces a transmit field of up to 7 mTp continuous, requiring a reactive power of 0.5 MW. As a general-purpose system, the imaging FOV is limited by coil size, and we set it to 23 x 23 x 6 cm3 to match FOVs seen in MRI head imaging.  We present imaging results of phantoms filled with VivoTrax (Magnetic Insight, Inc.) tracer, including spiral phantoms, sensitivity, resolution, and dynamic range phantoms. We conclude by demonstrating safe, magnetostimulation-free imaging sequences in the feet of three healthy volunteers.  

Article Details


[1] E. Mattingly, E. E. Mason, M. Sliwiak, and L. L. Wald, ‘Drive and receive coil design for a human-scale MPI system’, Int J Magn Part Imaging, vol. 8, no. 1, 2022, doi: 10.18416/ijmpi.2022.2203075.

[2] M. Graeser et al., ‘Human-sized magnetic particle imaging for brain applications’, Nat Commun, vol. 10, no. 1, 2019, doi: 10.1038/s41467-019-09704-x.

[3] P. Vogel et al., ‘iMPI: portable human-sized magnetic particle imaging scanner for real-time endovascular interventions’, Sci Rep, vol. 13, no. 1, Dec. 2023, doi: 10.1038/s41598-023-37351-2.

[4] J. Rahmer, D. Wirtz, C. Bontus, J. Borgert, and B. Gleich, ‘Interactive Magnetic Catheter Steering with 3-D Real-Time Feedback Using Multi-Color Magnetic Particle Imaging’, IEEE Trans Med Imaging, vol. 36, no. 7, pp. 1449–1456, Jul. 2017, doi: 10.1109/TMI.2017.2679099.

[5] C. Bontus, B. Gleich, B. David, O. Mende, and J. Borgert, ‘Concept of a Generator for the Selection and Focus Field of a Clinical MPI Scanner’, IEEE Trans Magn, vol. 51, no. 2, Feb. 2015, doi: 10.1109/TMAG.2014.2326003.

[6] T.-A. Le, M. P. Bui, K. M. Gadelmowla, S. Oh, and J. Yoon, ‘First Human-scale Magnetic Particle Imaging System with Superconductor’, Int J Magn Part Imaging, vol. 9, no. 1, 2023, doi: 10.18416/ijmpi.2023.2303032.

[7] A. A. Ozaslan, M. Utkur, U. Canpolat, M. A. Tuncer, K. K. Oguz, and E. U. Saritas, ‘PNS Limits for Human Head-Size MPI Systems: Preliminary Results’, Int J Magn Part Imaging, vol. 8, no. 1 Suppl 1, Mar. 2022, doi: 10.18416/IJMPI.2022.2203028.

[8] I. Schmale et al., ‘Human PNS and SAR study in the frequency range from 24 to 162 kHz’, 2013 International Workshop on Magnetic Particle Imaging, 2013, doi: 10.1109/IWMPI.2013.6528346.

[9] E. U. Saritas, P. W. Goodwill, G. Z. Zhang, and S. M. Conolly, ‘Magnetostimulation limits in magnetic particle imaging’, IEEE Trans Med Imaging, vol. 32, no. 9, pp. 1600–1610, 2013, doi: 10.1109/TMI.2013.2260764.

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