International Journal on Magnetic Particle Imaging IJMPI
Vol. 12 No. 1 Suppl 1 (2026): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2026.2603047

Proceedings Articles, ID 929

Large core & small shell particles facilitate physiological viscosity differentiation via MPS

Main Article Content

Sandra Bolte (Department of Medical Engineering and Applied Mathematics, FH Aachen University of Applied Sciences, Jülich, Germany), Beril Simsek (Department of Medical Engineering and Applied Mathematics, FH Aachen University of Applied Sciences, Jülich, Germany), Mohamad Bilal Abbas (Department of Medical Engineering and Applied Mathematics, FH Aachen University of Applied Sciences, Jülich, Germany), Hans-Joachim Krause (Institute of Biological Information Processing, Forschungszentrum Jülich, Jülich, Germany), Ulrich Engelmann (Department of Medical Engineering and Applied Mathematics, FH Aachen University of Applied Sciences, Jülich, Germany)

Copyright (c) 2026 Sandra Bolte, Beril Simsek, Mohamad Bilal Abbas, Hans-Joachim Krause, Ulrich Engelmann

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Magnetic nanoparticles (MNP) are researched for in-vivo applications and represent a key tool in both therapy via magnetic fluid hyperthermia (MFH) and diagnostics using magnetic particle spectroscopy (MPS) and imaging (MPI). In-vivo, MNP are exposed to various physiological environments, binding to blood and cells and are thereby subjected to constantly changing conditions. In this simulative work, the performance of MNP in MPS was investigated with regard to core size, hydrodynamic size and distribution width and under different physiological viscosities of water, blood and inside cells. Our preliminary results from stochastic Neel-Brownian coupled relaxation dynamics simulations suggest that for MPS, differentiation of MNP binding states across water, blood, and intracellular environments appears feasible for MNP of large cores above 20 nm with small hydrodynamic sizes below 50 nm.

Article Details

References

[1] U. M. Engelmann et al. „Combining bulk temperature and nanoheating enables advanced magnetic fluid hyperthermia efficacy on pancreatic tumor cells”, Scientific Reports, vol. 8, no. 1, pp. 13210, 2018, doi: 10.1038/s41598-018-31553-9.

[2] E. Teeman, C. Shasha, J. E. Evans and K. M. Krishnan, “Intracellular dynamics of superparamagnetic iron oxide nanoparticles for magnetic particle imaging”, Nanoscale, vol. 11, no. 16, pp. 7771-7780, 2019, doi: 10.1039/c9nr01395d.

[3] U. M. Engelmann, C. Shasha and I. Slabu, Magnetic Nanoparticle Relaxation in Biomedical Application, in Magnetic Nanoparticles in Human Health and Medicine: Current Medical Applications and Alternative Therapy of Cancer, 1st ed., C. Caizer, Ed. Hoboken, John Wiley & Sons, 2021, pp. 327–354, doi: 10.1002/9781119754725.ch15.

[4] U. M. Engelmann, A. Shalaby, C. Shasha, K. M. Krishnan, and H.-J. Krause, "Comparative Modeling of Frequency Mixing Measurements of Magnetic Nanoparticles Using Micromagnetic Simulations and Langevin Theory," Nanomaterials, vol. 11, no. 5, 2021, doi: 10.3390/nano11051257.

[5] O. E. Puchkov et al. "Intracellular viscosity: Methods of measurement and role in metabolism." Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, vol. 7 no. 4, pp. 270-279, 2013, doi: 10.1134/S1990747813050140.

[6] A.S. Kashirina et al. "Monitoring membrane viscosity in differentiating stem cells using BODIPY-based molecular rotors and FLIM" Scientific Reports, vol. 10, no. 1, pp. 14063, 2020, doi: 10.1038/s41598-020-70972-5.

[7] H.-J. Krause and U. M. Engelmann “Fundamentals and Applications of Dual-Frequency Magnetic Particle Spectroscopy: Review for Biomedicine and Materials Characterization”, Advanced Science, vol. 12, no. 13, pp. 2416838, 2025, doi: 10.1002/advs.202416838.

[8] K. Rathi et al. “Assessment of differential magnetic susceptibility in nanoparticles: Effects of changes in viscosity and immobilisation”, Journal of Magnetism and Magnetic Materials, vol. 514, no. 167238, 2020, doi: 10.1016/j.jmmm.2020.167238.

[9] A. Remmo et al. “ Immobilization-induced anomalous dynamic magnetization effect in synomag nanoparticles as tracers for magnetic particle imaging”, ACS Applied Nano Materials, vol. 7, no. 21, pp. 24315–24324, 2024, doi: 10.1021/acsanm.4c01523.

Most read articles by the same author(s)