International Journal on Magnetic Particle Imaging IJMPI
Vol. 12 No. 1 Suppl 1 (2026): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2026.2604002
Proceedings Articles, ID 957
Relaxation-induced stimulated emission depletion (ReSTED) magnetic particle imaging
Main Article Content
Copyright (c) 2026 Guang Jia, Wenlong Li, Yongchen Gou, Zhongwei Bian, Zhiyuan Zhao, Tianshu Li, Jing Zhong, Zechen Wei, Bingye Wang, Jia Luo, Mingli Peng, Weihua Li, Shi Bai, Peng Gao, Tanping Li, Hui Hui, Jie Tian
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abstract
Stimulated emission depletion (STED), widely used in fluorescence microscopy with a key donut-shaped PSF, is
rarely appliedtootherbiomedicalimaging. Magneticparticleimaging(MPI),anon-ionizingtechniquefordetecting
magnetic nanoparticles, has Gaussian PSF (from field-free line/FFL harmonic signals) with limited resolution.
Theimaginary part of a point source’s harmonic signal in MPI can form a donut-shaped PSF. Based on difference
of Gaussian (DoG) theory, subtracting this donut PSF from Gaussian PSF yields a STED PSF with 3–4x higher
resolution. In human brain FFL-MPI simulation, STED acquired donut-PSF projected signals, and super-resolution
images were reconstructed via 1D deconvolution, filtered backprojection, or Richardson–Lucy with total-variation
regularization.