International Journal on Magnetic Particle Imaging IJMPI
Vol. 12 No. 1 Suppl 1 (2026): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2026.2604002

Proceedings Articles, ID 957

Relaxation-induced stimulated emission depletion (ReSTED) magnetic particle imaging

Main Article Content

Guang Jia (Xidian University), Wenlong Li (Xidian University), Yongchen Gou (Xidian University), Zhongwei Bian (Beihang University), Zhiyuan Zhao (University of Chinese Academy of Sciences), Tianshu Li (Shenyang University of Technology), Jing Zhong (Beihang University), Zechen Wei (Chinese Academy of Sciences), Bingye Wang (Chinese Academy of Sciences), Jia Luo (Northwest University), Mingli Peng (Northwest University), Weihua Li (Peking University), Shi Bai (Shenyang University of Technology), Peng Gao (Xidian University), Tanping Li (Xidian University), Hui Hui (Chinese Academy of Sciences), Jie Tian (Chinese Academy of Sciences)

Copyright (c) 2026 Guang Jia, Wenlong Li, Yongchen Gou, Zhongwei Bian, Zhiyuan Zhao, Tianshu Li, Jing Zhong, Zechen Wei, Bingye Wang, Jia Luo, Mingli Peng, Weihua Li, Shi Bai, Peng Gao, Tanping Li, Hui Hui, Jie Tian

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Stimulated emission depletion (STED), widely used in fluorescence microscopy with a key donut-shaped PSF, is
rarely appliedtootherbiomedicalimaging. Magneticparticleimaging(MPI),anon-ionizingtechniquefordetecting
magnetic nanoparticles, has Gaussian PSF (from field-free line/FFL harmonic signals) with limited resolution.
Theimaginary part of a point source’s harmonic signal in MPI can form a donut-shaped PSF. Based on difference
of Gaussian (DoG) theory, subtracting this donut PSF from Gaussian PSF yields a STED PSF with 3–4x higher
resolution. In human brain FFL-MPI simulation, STED acquired donut-PSF projected signals, and super-resolution
images were reconstructed via 1D deconvolution, filtered backprojection, or Richardson–Lucy with total-variation
regularization.

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