International Journal on Magnetic Particle Imaging IJMPI
Vol. 12 No. 1 Suppl 1 (2026): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2026.2603039

Proceedings Articles, ID 988

Background-free reconstruction in magnetic particle imaging via differential offset fields

Main Article Content

Penghua Zhai (1) School of Engineering Medicine, Beihang University, Beijing, China; 2) Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of the People’s Republic of China, Beijing, China), Zhongwei Bian (1) School of Engineering Medicine, Beihang University, Beijing, China;2) Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of the People’s Republic of China, Beijing, China), Weixin Xu (1) School of Engineering Medicine, Beihang University, Beijing, China; 2) Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of the People’s Republic of China, Beijing, China), Jie Tian (1) School of Engineering Medicine, Beihang University, Beijing, China; 2) Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of the People’s Republic of China, Beijing, China), Wei Mu (1) School of Engineering Medicine, Beihang University, Beijing, China; 2) Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of the People’s Republic of China, Beijing, China)

Copyright (c) 2026 Penghua Zhai, Zhongwei Bian, Weixin Xu, Jie Tian, Wei Mu

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Magnetic particle imaging (MPI) is a promising molecular imaging technique that enables quantitative visualization of the distribution of magnetic nanoparticles (MNPs). Yet, background signal affects the accurate quantitative assessment of MNPs. To suppress background signal, a common practice is to initially measure the background and subtract it during subsequent MNPs signal acquisition. However, frequent background measurements not only reduce imaging efficiency but can also introduce additional noise and repositioning artifacts. Here, we propose a background-free reconstruction method to eliminate dedicated background measurement. Specifically, a pair of differential symmetric offset fields are sequentially applied to excitation field, and the differential signal between two acquisitions yields a pure MNPs response. Simulation results show that the approach significantly enhances imaging quality compared to background measurement.

Article Details

References

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