International Journal on Magnetic Particle Imaging IJMPI
Vol. 12 No. 1 Suppl 1 (2026): Int J Mag Part Imag
https://doi.org/10.18416/IJMPI.2026.2604003

Proceedings Articles, ID 999

A mixing-frequency magnetic particle imaging system for high-throughput in-vivo imaging

Main Article Content

Shaoqi Sun (School of Instrumentation and Opto-Electronic Engineering, Ministry of Education Key Laboratory of Precision Opto-Mechatronics Technology, Beihang University, Beijing, China), Shijie Sun (School of Instrumentation and Opto-Electronic Engineering, Ministry of Education Key Laboratory of Precision Opto-Mechatronics Technology, Beihang University, Beijing, China), Rong Cai (School of Engineering Medicine, Key Laboratory of Biomechanics and Mechanobiology, Beihang University, Beijing, China), Lijun Xu (School of Instrumentation and Opto-Electronic Engineering, Ministry of Education Key Laboratory of Precision Opto-Mechatronics Technology, Beihang University, Beijing, China), Jing Zhong (Beihang University)

Copyright (c) 2026 Shaoqi Sun, Shijie Sun, Rong Cai, Lijun Xu, Jing Zhong

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

A mixing-frequency magnetic particle imaging (MPI) system is presented for high-throughput in-vivo studies. Coprime AC magnetic fields at 4.98 kHz and 97 Hz produce a field-free-point (FFP) scan in the x–y plane, which drive the MNPs to generate rich high-order harmonics and mixing-frequency components. All the mixing-frequency spectra of the MNPs are measured for image reconstruction. Phantom experimental results demonstrate the spatial resolution better than 1.5 mm at gradients of 0.64 T/m (x) and 1.28 T/m (y), and a limit of detection of 34.9 µmol/L Fe (?195 ng Fe). A scanning coil enables the 3D imaging speed of 0.5 min. A in-vivo murine study of cerebral blood-flow (CBF) imaging was acquired within a 30×30×30 mm³ FOV with clear delineation of anatomical structures. The mixing-frequency spectra-based approach combines hardware cost-effectiveness with good imaging performance, indicating strong potential for tumor diagnosis, cerebral perfusion, and longitudinal drug monitoring.

Article Details

References

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