International Journal on Magnetic Particle Imaging IJMPI
Vol. 8 No. 1 Suppl 1 (2022): Int J Mag Part Imag

Proceedings Articles

In vivo therapeutic cell tracking using magnetic particle imaging

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Renesmee Kuo , Prashant Chandrasekharan (University of California, Berkeley), Barry Fung (University of California, Berkeley), Steven Conolly (University of California, Berkeley)


White blood cells (WBCs) are a key component of our immune system. They play an essential role in surveillance, defense and adaptation against foreign pathogens during an immune response. Immunotherapies and immunomodulatory medications have become indispensable for treating cancer and immune disorders. Hence, imaging the immune response could help medicine diagnose and treat infections, inflammatory diseases like cardiovascular disease, and cancer. Currently, doctors rely on imaging tools like In-111 WBC scans to visualize the immune response. However, these tools destroy CAR-T and CAR-NK cells with radiation before they home to a tumor. A new biomedical imaging tool, Immuno-MPI, could remedy this pitfall and help doctors and researchers optimize immunotherapy for solid tumors. MPI uses no radiation to track cells. Its tracers also have infinite persistence. Here, we compare the effects and sensitivity limits of MPI to In111-WBC scintigraphy.

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