International Journal on Magnetic Particle Imaging IJMPI
Vol 9 No 1 Suppl 1 (2023): Int J Mag Part Imag
High resolution magnetic nanoparticle tracers for CAR-T cell tracking, stroke, GI bleed and pulmonary embolism imaging in Magnetic Particle Imaging
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Magnetic Particle Imaging (MPI) is a breakthrough in medical imaging technology. MPI already showed great promise towards cancer, gastrointestinal bleeds, pulmonary embolisms, stroke and WBC imaging, and it could soon provide a rapid, high-resolution and zero-radiation alternative to Nuclear Medicine studies like PET and SPECT. MPI could soon give unequivocal CAR-T cell immunotherapy treatment efficacy feedback in just 3 days instead of 3 months, allowing nimble treatment optimization for each patient. Currently, the biggest obstacle in MPI is the poor spatial resolution of MPI tracers. In this work, we report a recently discovered commercially available tracer — Synomag®-D — that shows a 3.5-fold resolution boost when imaged with a weaker drive field. This resolution boost could reduce the gradient cost and hardware constraints and bring MPI a step closer to clinical translation.