High resolution magnetic nanoparticle tracers for CAR-T cell tracking, stroke, GI bleed and pulmonary embolism imaging in Magnetic Particle Imaging

Abstract

Magnetic Particle Imaging (MPI) is a breakthrough in medical imaging technology. MPI already showed great promise towards cancer, gastrointestinal bleeds, pulmonary embolisms, stroke and WBC imaging, and it could soon provide a rapid, high-resolution and zero-radiation alternative to Nuclear Medicine studies like PET and SPECT. MPI could soon give unequivocal CAR-T cell immunotherapy treatment efficacy feedback in just 3 days instead of 3 months, allowing nimble treatment optimization for each patient. Currently, the biggest obstacle in MPI is the poor spatial resolution of MPI tracers. In this work, we report a recently discovered commercially available tracer — Synomag®-D — that shows a 3.5-fold resolution boost when imaged with a weaker drive field. This resolution boost could reduce the gradient cost and hardware constraints and bring MPI a step closer to clinical translation.