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A major advantage of MPI compared to other in vivo imaging modalities is a linear relationship between the label (SPIO) concentration and MPI signal. However, the MPI signal can be affected by intrinsic tissue matrix parameters, which are often not known a priori, presenting challenges for proper SPIO quantification in vivo. We report here on the effects of matrix compressibility and temperature on MPI signal in tissue-mimicking phantoms, which has direct relevance to MPI-guided magnetic fluid hyperthermia.
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