International Journal on Magnetic Particle Imaging IJMPI
Vol. 9 No. 1 Suppl 1 (2023): Int J Mag Part Imag

Short Abstracts

Smart intratumoral delivery of theranostic gold-iron oxide nanoflowers in prostate cancer using tumor-tropic mesenchymal stem cells

Main Article Content

Behnaz Ghaemi , Ana Rosu (Johns Hopkins University), Chao Wang (Johns Hopkins University), Gautier Laurent (Université de Franche-Comté), Rana Bazzi (Université de Franche-Comté), Stéphane Roux (Université de Franche-Comté), Ali Shakerizadeh (Johns Hopkins University), Jeff W. M. BULTE (Johns Hopkins University)


Passive and active targeting of therapeutic nanoparticles (NPs) toward cancer cells has been challenging. New approaches are developed to obtain a more effective targeting method for uniform distribution of NPs within the tumor. We have used tumor-tropic human mesenchymal stem cells (hMSCs) labeled with gold-decorated iron oxide nanoflowers (GIONF) to deliver and retain these theranostic NPs within prostate tumors. GIONF-hMSCs were effective MPI and photothermal therapy (PTT) agents. After i.t. injection in vivo, GIONF-hMSCs remained within tumors for a week without change of MPI signal, while GIONFs alone (“naked” GIONFs) had a ten-fold reduction in MPI signal. We demonstrate the feasibility of imaging GIONF-hMSCs with MPI and CT as a theranostic delivery system for prostate cancer, with improved retention and biodistribution of GIONF-hMSCs compared to naked GIONFs.

Article Details


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