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Copyright (c) 2022 Renesmee Kuo, Barry Fung, Prashant Chandrasekharan, Quincy Huynh, Chinmoy Saayujya, Jacob Bryan, Kim Hwang Yeo, Irati Rodrigo, Benjamin Fellows, Steven Conolly
This work is licensed under a Creative Commons Attribution 4.0 International License.
Bone marrowserves a crucial role in the body, producing hematopoietic stem cells and blood products. Imaging bone marrow could help doctors determine bone marrow disorders and have an early understanding of the metastatic distribution of tumors in the bone. Colloidal tracers that target the reticuloendothelial system (RES) such as the liver, spleen and bone marrow are commonly used to image bone marrow. Alternatively, antibodies specific to granulocytes, especially neutrophils, can be used to image the myeloid distribution of bone marrow. Using antibody functionalized superparamagnetic iron oxide (SPIO) nanoparticles as tracers, magnetic particle imaging (MPI) could image bone marrow in vivo. In this work, we imaged bone marrow in vivo using anti-Ly6G antibody functionalized nanoparticles that are specific towards surface antigens expressed on granulocytes.